Sanhuangzhan 2 (SHZ-2), an indica cultivar, has been planted in South China for more than 10 years and showed durable resistance to blast. Inoculation and multi-locational tests indicated that SHZ-2 not only had a broad spectrum of resistance to the Chinese blast isolates, but also had a high frequency of resistance to the Philippine isolates (98%), and its leaf blast and neck blast resistance in International Rice Blast Nurseries (IRBN) were as good as or even better than OS6,Moroberekan and IR36 which were recognized as cultivars with durable resistance to blast. High level of quantitative resistance to blast in SHZ-2 was also recorded after it was infected by compatible isolates. The results from analysis of disease resistance in recombinant inbred lines derived from cross between SHZ-2 and Lijiangxintuanheigu(LTH) in different inoculation and field tests suggested that the blast qualitative resistance in SHZ-2 was controlled by multiple major genes, and its blast quantitative resistance was race-non specific. With candidate resistance gene approach, three major genes associated with blast qualitative resistance and five defense response gene markers significantly associated with blast quantitative resistance in SHZ-2 were identified. Research results suggest that the both combination of broad spectrum of blast qualitative resistance and high level of blast quantitative resistance in SHZ-2 contributes to its durable blast resistance. Advanced backcrossed and molecular-assisted selection was performed to introduce the blast resistance genes from SHZ-2 into Texianzhan 13(TXZ-13), an indica type cultivar with high yielding and good quality but susceptible to blast. Several new resistance lines bearing several major genes and QTLs were obtained.