·常规信息
基因(座)名称斑点叶基因; E3泛素连接酶
spotted leaf-11; E3 Ubiquitin Ligase
基因符号Spl11
所在染色体12 (已克隆)

SPL11(AY652589/AY652590, Zeng et al. 2004)...

Spl-11基因位点,控制水稻斑点叶的产生。这一性状与病原菌诱导的发病症状很相似。

【突变体表型】

spl2, spl7, spl11突变体在受真菌诱导物处理时细胞中积累更多的H2O2。当抑制NADPH 氧化酶活性时,spl突变体细胞中活性氧的积累会受到抑制,臭氧辐射spl突变体时也观察到相同的现象(Kojo et al., 2006)。

铁锈斑在分蘖后期出现,一直持续到成熟期。斑点分布到整个叶片上,在中脉集中最多。

spl11携带有对稻瘟病菌和白叶枯病菌的非小种专化的广谱抗性(Yin et al. 2000)。

【生物学功能】

spl2, spl7, spl11 突变体丧失了对NADPH 氧化酶的调节(Kojo et al., 2006)。

在体外,SPL11能够对SPIN6泛素化;在体内,SPL11能通过26S蛋白酶体途径降解SPIN6(Liu et al., 2015)。

SPL11在细胞核能够与SPIN1互作,并可能通过泛素化作用,负调控开花负调控因子SPIN1(Vega-Sánchez et al. 2008)。

Spl11负调控Rbs1,参与水稻花期的调控(Cai et al. 2014)。

【相关登录号】
contigs及其产物:AP008218BAF30096
cDNAs及其产物:AY652589AAT94160, AY652590AAT94161
参考基因组位点:Os12g0570000(RAP-DB, Gramene←→ LOC_Os12g38210(本地MSU-RGAP
参考基因组产物:NM_001073609NP_001067077
uniprot库登录号:Q0IMG9
将本文分享到:
·ONTOLOGY及相关基因
表型特征稻瘟病抗性(TO:0000074), 白叶枯病抗性(TO:0000175), 抽穗期(TO:0000137), 斑叶坏死(TO:0000070)
分子功能蛋白质结合(GO:0005515), 泛素连接酶活性(GO:0004842)
生物进程蛋白质泛素化(GO:0016567), 细胞程序化死亡调节(GO:0043067), 光周期-开花调控(GO:2000028)
形态构造维管叶(PO:0009025)
·参考文献
1Jinling Liu;Chan Ho Park;Feng He;Minoru Nagano;Mo Wang;Maria Bellizzi;Kai Zhang;Xiaoshan Zeng;Wende Liu;Yuese Ning;Yoji Kawano;Guo-Liang Wang
  The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice
  PLoS Pathogens, 2015, 11(2): e1004629
2Yuhui Cai;Miguel E. Vega-Sánchez;Chan Ho Park;Maria Bellizzi;Zejian Guo;Guo-Liang Wang
  RBS1, an RNA Binding Protein, Interacts with SPIN1 and Is Involved in Flowering Time Control in Rice
  PLoS ONE, 2014, 9(1): e87258
3Miguel E. Vega-Sánchez;Lirong Zeng;Songbiao Chen;Hei Leung;Guo-Liang Wang
  SPIN1, a K Homology Domain Protein Negatively Regulated and Ubiquitinated by the E3 Ubiquitin Ligase SPL11, Is Involved in Flowering Time Control in Rice
  The Plant Cell, 2008, 20(6): 1456-1469
4Kaori Kojo;Takashi Yaeno;Kensuke Kusumi;Hideo Matsumura;Shizuko Fujisawa;Ryohei Terauchi;Koh Iba
  Regulatory mechanisms of ROI generation are affected by rice spl mutations
  Plant and Cell Physiology, 2006, 47(8): 1035-1044
5Li-Rong Zeng;Shaohong Qu;Alicia Bordeos;Chengwei Yang;Marietta Baraoidan;Hongyan Yan;Qi Xie;Baek Hie Nahm;Hei Leung;Guo-Liang Wang
  Spotted leaf11, a Negative Regulator of Plant Cell Death and Defense, Encodes a U-Box/Armadillo Repeat Protein Endowed with E3 Ubiquitin Ligase Activity
  The Plant Cell, 2004, 16(10): 2795-2808
6L. Zeng;Z. Yin;J. Chen;H. Leung;G.-L. Wang
  Fine genetic mapping and physical delimitation of the lesion mimic gene Spl11 to a 160-kb DNA segment of the rice genome
  Molecular Genetics and Genomics, 2002, 268(2): 253-261
7Zhongchao Yin;Jun Chen;Lirong Zeng;Meiling Goh;Hei Leung;Gurdev S. Khush;Guo-Liang Wang
  Characterizing Rice Lesion Mimic Mutants and Identifying a Mutant with Broad-Spectrum Resistance to Rice Blast and Bacterial Blight
  Molecular Plant-Microbe Interactions, 2000, 13(8): 869-876
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